This workshop aims to illustrate how transformative and collaborative digitally-enhanced practices can be designed, in keeping with a design for learning approach fostering students’ active learning and agency (Goodyear 2015; Rapanta et al. 2020), to implement online CLIL (Content and Language Integrated learning) courses at the tertiary level. To this purpose, a digitally-enhanced framework developed from a pedagogy of care perspective (Jackson 2021) and suitable for designing flexible online CLIL courses will be presented.